PGC-1α Is a Master Regulator of Mitochondrial Lifecycle and ROS Stress Response | RTCL.TV

Pgc 1 plays a critical role in mitochondrial function and ROS metabolism. It is regulated by several factors, including SIRT1, 3 TFAM, and AMPK, as well as NF B, which is involved in both the immune system and oxidative stress.

Under inflammatory conditions, NF B reduces PGC 1 expression and activity leading to decreased antioxidants.

Gene expression and increased oxidative stress This results in a vicious cycle whereby low PGC 1 levels lead to further oxidative stress, which in turn, increases NF B activity.

Perpetuating the inflammatory response.

This article was authored by Othman Abu Shelbayeh, Tasnim, Arroum, Silke Morris, and others.

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