Pgc 1 plays a critical role in mitochondrial function and ROS metabolism. It is regulated by several factors, including SIRT1, 3 TFAM, and AMPK, as well as NF B, which is involved in both the immune system and oxidative stress. Under inflammatory conditions, NF B reduces PGC 1 expression and activity leading to decreased antioxidants. Gene expression and increased oxidative stress This results in a vicious cycle whereby low PGC 1 levels lead to further oxidative stress, which in turn, increases NF B activity. Perpetuating the inflammatory […]

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